Logic Synthesis as an Efficient Means of Minimal Model Discovery from Multivariable Medical Datasets

In this paper we review the application of logic synthesis methods for uncovering minimal structures in observational/medical datasets. Traditionally used in digital circuit design, logic synthesis has taken major strides in the past few decades and forms the foundation of some of the most powerful concepts in computer science and data mining. Here we provide a review of current state of research in application of logic synthesis methods for data analysis and provide a demonstrative example for systematic application and reasoning based on these methods

A Network-Based Deterministic Model for Causal Complexity

Despite the widespread use of techniques and tools for causal analysis, existing methodologies still fall short as they largely regard causal variables as independent elements, thereby failing to appreciate the significance of the interactions of causal variables. The prospect of inferring causal relationships from weaker structural assumptions compels for further research in this area. This study explores the effects of the interactions of variables in the context of causal analysis, and introduces new advancements to this area of research. In this study, we introduce a new approach for the causal complexity with the goal of making the solution set closer to deterministic by taking into consideration the underlying patterns embedded within a dataset; in particular, the interactions of causal variables. Our model follows the configurational approach, and as such, is able to account for the three major phenomena of conjunctural causation, equifinality, and causal asymmetry

Derivation and Analysis of Dynamic Handwriting Features as Clinical Markers of Parkinson’s Disease

Parkinson’s Disease (PD) is a complex neurodegenerative disorder that is challenging to diagnose. Recent research has demonstrated predictive value in the analysis of dynamic handwriting features for detecting PD, however, consensus on clinically-useful features is yet to be reached. Here we explore and evaluate secondary kinematic handwriting features hypothesized to be diagnostically relevant to Parkinson’s Disease using a publicly-available Spiral Drawing Test PD dataset. Univariate and multivariate analysis was performed on derived features. Classification outcome was determined using logistic regression models with 10-fold cross validation. Feature correlation was based on model specificity and sensitivity. Variations in grip angle, instantaneous acceleration and pressure indices were found to have high predictive potential as clinical markers of PD, with combined classification accuracy of above 90%. Our results show that the significance of secondary handwriting features and recommend the feature expansion step for hypothesis generation, comparative evaluation of test types and improved classification accuracy